Kathy A. Suprenant
Professor Emeritus, Department of Molecular Biosciences
1200 Sunnyside Avenue
University of Kansas
Lawrence, Kansas 66045-7534
EDUCATION
State University of New York at Albany
Bachelor of Science, Biological Science (honors), 1977
University of Virginia, Charlottesville
Doctor of Philosophy, Biology, 1982
University of California, Santa Barbara
Postdoctoral Fellow, Biochemistry and Molecular Biology, 1982-1984
University of Kansas Center for Biomedical Research, Lawrence
Postdoctoral Fellow, 1984-1985
ACADEMIC & ADMINISTRATIVE APPOINTMENTS
American Cancer Society Postdoctoral Research Fellow, University of
California, Santa Barbara, 1982-1984; University of Kansas 1984-1985
Instructor, University of Kansas, 1985-1987
Assistant professor, University of Kansas, 1987-1991
Genetics Program Faculty, University of Kansas, 1990-2016
Associate professor, University of Kansas, 1991-1996
Visiting Scientist, Department of Genetics and Cell Biology, University of Minnesota, St. Paul, 1995-1996
Professor, University of Kansas, 1996-2016
Chair, Department of Molecular Biosciences, University of Kansas, 2004-2008
Co-Chair, Division of Biological Sciences, University of Kansas, 2006-2008
Computational Program Faculty, University of Kansas, 2005-2016
PROFESSIONAL APPOINTMENTS
Corporation member, Marine Biological Laboratory Corporation, Woods Hole, MA (1988-2013)
Member American Association for the Advancement of Science, American Society for Cell Biology, Genetics Society of America, Society of Developmental Biologists (at various times since 1982)
Member, NSF Neuronal and Glial Mechanisms Grants Advisory Panel, 1991-92
Member, NSF Molecular and Cellular Biology Grants Advisory Panel 1990-96
Member, Kansas Masonic Cancer Research Institute, University of Kansas Medical Center, 2005-2016
Member, Information and Telecommunications Technology Center Industry Advisory Board, 2005-2008
Member, Kansas University Center for Research (KUCR) Board of Trustees, 2005-2008
Executive Committee Member for KUCR Board of Trustees, 2005-2010
Editorial Board, Biological Bulletin, Marine Biological Laboratory, Woods Hole, MA, 2010-2014
Member, NSF Pre-proposal Review Panel for Division of Integrative Organismal System, 2013
AWARDS
New York State Regents Scholar, SUNY, Albany, 1973-1977
Pratt Predoctoral Fellow, University of Virginia, 1979-1980
DuPont Predoctoral Fellow, University of Virginia, 1980-1981
NIH Predoctoral Traineeship, 1981-1982
California Cancer Research Committee Postdoctoral Fellow, 1982-1983.
American Cancer Society Postdoctoral Fellow, 1983-1984
Mortar Board Outstanding Educator Award, University of Kansas, 1986
Marine Biological Laboratory Summer Fellow, 1987, 1988
Robert Day Allen Fellow, Marine Biological Laboratory, 1987, 1988
Professional Opportunities for Women in Research and Engineering Award, National Science Foundation, 1993-1994
Career Advancement Award, National Science Foundation, 1995-1996
Inez Jay Research Award, Higuchi Bioscience Center, University of Kansas, 1997-1998
International Union Against Cancer Award, 2003
Senior Administrative Fellows Program, University of Kansas, 2003-2004
ADVANCE Leadership Institute Scholarship, Midwest Center for Non-profit Leadership, University of Missouri, Kansas City, 2004
Inductee, University of Kansas Women’s Hall of Fame, 2006
EXTERNAL GRANT FUNDING
NIH RO1 (CA105305)
“A yeast model for determining tubulin-drug interactions”
R. Himes, P.I., K. Suprenant, Co.I., G. Georg, Co.I.
2004-2008, Total award: $1,062,720.
NIH (IP20RR15563-01)
“Center for Cancer Experimental Therapeutics”
G. Georg, P.I.
Subproject: Y. Azuma, P.I.
“Function of mitotic SUMOylation on genomic instability”
Mentor: K. Suprenant
2006-2008, 5% effort
NIH (P20 RR016475)
J. Hunt, P.I.
Subproject: K. Suprenant, P.I.
Cellular Defects of a Modified Dystrophinopathy
2005-2006, Total award: $35,000.
National Science Foundation (MCB-9982377)
K. Suprenant, P.I.
“CeEMAP-95 function in the nematode, C. elegans”
2000-2006, Total award: $661,000
NIH (IP20RR15563-01)
“Center for Cancer Experimental Therapeutics”
G. Georg, P.I.
One of five subprojects submitted in the original COBRE submission-reviewed nationally:
K. Suprenant, P.I.
“On the Function of Vaults in Multi-drug Resistant Cancer Cells”
2000-2003, Total direct costs: $278,324
Research Experiences for Undergraduates (REU) Award Supplements (16 individual awards) to NSF grants (DCB-9003544, MCB-9315700, MCB-9982377), 1991-2004
K. Suprenant, P.I
National Science Foundation (MCB-9315700)
K. Suprenant, P.I.
“Cell Cycle Regulation of Microtubule Assembly”
1994-1999, Total award: $575,958
National Science Foundation Career Advancement Award (MCB-9509865)
K. Suprenant, P.I.
“Modifiers of dynein function in Drosophila”
1995-1996, Total award: $50,000
Professional Opportunities for Women in Research and Engineering (MCB-9307112)
K. Suprenant, P.I.
“Polyribosome Targeting to Microtubules”
1993-1994, Total award: $45,000
The Council for Tobacco Research (CTR 2874)
K. Suprenant, P.I.
“End-dependent regulators of microtubule assembly”
1994-1998, Total award: $523,000
The Council for Tobacco Research (CTR 2874)
K. Suprenant, P.I.
“End-dependent regulators of microtubule assembly”
1991-1994
National Science Foundation (DCB-9003544)
K. Suprenant, P.I. “Cell Cycle Regulation of Microtubule Assembly”
1990-1994, Total award: $280,000
National Science Foundation (DCB-8616215)
K. Suprenant, P.I. “Calcium homeostasis in the mitotic apparatus”
1986-1990, Total award: $258,451
INVITED SYMPOSIA PRESENTATIONS
New York Academy of Sciences Conference on the Dynamic Aspects of Microtubule Biology, New York, NY, 1984
Science Writing Seminar Series, Marine Biological Laboratory, Woods Hole, MA, 1987
Chairperson and Moderator, Cell Biology Session, General Scientific Meetings, Marine Biological Laboratory, Woods Hole, 1988
Chairperson and Moderator, Cell Biology Session, General Scientific Meetings, Marine Biological Laboratory, Woods Hole, 1989
Sea Urchin Development Meetings, Marine Biological Laboratory, Woods Hole, 1991
Junior Science and Humanities Symposium. Academy of Applied Science, US Army, Lawrence, KS, 1992
Chairperson and speaker, FASEB Symposium on Sorting and Intracellular Transport of RNA, Santa Clara, California, 1994
Chairperson and speaker, Sea Urchin Development IX meetings, Marine Biological Laboratory, Woods Hole, MA, 1994
Gordon Conference, Enzyme Organization and Cell Function, Oxnard, CA, 1995
Symposium in honor of Dr. Lionel Rebhun, Department of Biology, University of Virginia, Charlottesville, 1996
Sea Urchin Development Meetings, Marine Biological Laboratory, Woods Hole, MA, 1996
FASEB Meeting, Sorting and Intracellular Transport of RNA, Snowmass, CO, 1996
Gordon Conference, Macromolecular Organization and Cell Function, Oxford, UK, 1996
French-American Colloquium on the Cytoskeleton and Human Disease, Marseille, France, 2001
First International Vault Meeting, Amsterdam, The Netherlands, 2002
INVITED SEMINARS
Marine Biological Laboratory, Woods Hole, MA, 1987
Mount Holyoke College, South Hadley, MA (Biology), 1989
University of Kansas, Lawrence (Physiology and Cell Biology), 1990
University of Kansas, Lawrence (Microbiology), 1991
University of Kansas Medical Center, Kansas City (Anatomy), 1991
University of Kansas, Lawrence (Pharmacology and Toxicology), 1991
Cell and Developmental Biology Seminar Series, Marine Biological Laboratory, Woods Hole, MA, 1991
Advanced Molecular Cloning Course, Cold Spring Harbor Laboratory, NY, 1992
University of Nebraska, Lincoln (Biological Sciences), 1993
University of Kansas, Lawrence (Physiology and Cell Biology), 1994
SUNY Buffalo Medical School (Anatomy), 1995
University of Missouri Medical School, Columbia (Physiology), 1995
University of Kansas Medical Center, Kansas City (Physiology), 1995
University of Minnesota, St. Paul (Genetics and Cell Biology) 1996
University of Oklahoma, Norman (Zoology), 1998
University of Kansas, Lawrence (Molecular Biosciences), 1998
Kansas State University, Manhattan (Biology), 1998
University of Kansas Medical Center (Anatomy and Cell Biology), 2000
University of California, Santa Barbara (Molecular, Cellular and Developmental Biology), 2001
Avila College (Science and Mathematics), Kansas City, MO, 2002
Russian Cancer Research Center, Moscow, Russia, 2004
Western Missouri State University, St. Josephs, MO 2004
William Jewell College, Liberty, MO 2005
Michigan State University, E. Lansing, MI 2007
TEACHING UNDERGRADUATE
BIOL 416: Cell Structure and Function (undergraduate, lecture, 3 credits, and 100% effort); 1987-1989; 1991-1994; 1997-2002; 2007, 2010-2015. Large survey core course required for biology and premedical majors.
BIOL 419: Topics in Advanced Biology (undergraduate honors seminar, 2 credits, 50% effort), 2005.
BIOL 420: Germ Cells and Fertilization (1 credit, 100 % effort), 1986
BIOL 420: Biology of Fertilization (1 credit, 100 % effort), 1989
BIOL 420: Mitosis and Cell Division (1 credit, 100 % effort) 1990.
BIOL 423: Non-laboratory Independent Study (variable credit, 100% effort), 2011: 2013
BIOL 424: Independent Research (variable credit, 100% effort); 1985-2014
BIOL 426: Laboratory in Cell Biology (undergraduate, laboratory, 3 credits, and 50-100 % effort); 1986; 1996; 2003-2007. In 2003, restructured entire lab to focus on advanced imaging and molecular analyses of cellular function.
BIOL 536: Cell Structure and Function (honors) (3 credits, 100% effort) 2012-2014
BIOL 599: Senior Seminar in Cell Biology (1 credit); 2006-2014
TEACHING GRADUATE
BIOL 701: Germ Cells and Fertilization (1 credit, 100 % effort), 1986
BIOL 701: Biology of Fertilization (1 credit, 100 % effort), 1989
BIOL 701: Mitosis and Cell Division (1 credit, 100 % effort), 1990
BIOL 701: Cell Cycle Regulation (1 credit, 100 % effort), 1993
BIOL 701: Microtubule Structure and Function (1 credit, 100 % effort), 1997-2003.
BIOL 752: Cell Biology (graduate, lecture, 3 credits, 25-50 % effort); 1991-1994; 1997-2006; 2008-2014.
BIOL 807: Graduate Molecular Biosciences (graduate, lecture, 6 credits, 9% effort); 2013.
RESEARCH TRAINEES UNDERGRADUATE
Approximately 60 undergraduates have carried out independent research projects in my laboratory as part of their education. Five of these students have written an honors thesis.
Ian Weidling. 2013. EML family of microtubule-binding proteins
Nate Bloom. 2003. Expression of major vault protein in response to stress. Patrick Everley. 2001. Localization of a Human EMAP-like Protein (ELP-2) in Cultured Mammalian Cells.
Kevin Cohoon. 1999. The Interaction of Vaults with the Echinoderm Microtubule-Associated Protein.
Amanda Hostetler*. 1995. A Developmental Characterization of a Microtubule-Associated Protein in Sea Urchins.
*published their research in peer-reviewed journals
RESEARCH TRAINEES GRADUATE
Andrew Box, M.A. 2006, Director of Flow Cytometry Lab at Stowers Medical Research Institute, Kansas City, MO.
Jennifer Hueston, Ph. D. 2005, currently a Director of Laboratories for undergraduate biology at the University of Kansas
Gina Purinton, M. A. 2003, currently a research assistant at University of North Carolina Medical Center, Durham, NC
Doug Ahrens, M. A. 1998, currently a Staff Scientist at Trimeris, Inc., Research Triangle, NC
Melissa Daggett, Ph. D. 1997, currently an Associate professor at Missouri Western State College, St. Josephs, MO
Danielle Hamill, Ph.D. 1997, currently an Associate professor at Ohio Wesleyan University, Delaware, OH
Ellen Brisch, Ph.D. 1995, currently an Professor and Chairperson at Minnesota State University, Moorehead
Qingwen Li, Ph.D. 1994, returned to China following post-doc with J. Mike Bishop, UC San Francisco
Jill Davis, M.A. 1992, formerly an instructor Rockhurst Community College, Kansas City, MO
RESEARCH TRAINEES POSTDOCTORAL
Jennifer Hueston, Ph. D. 2005-2007, currently a Director of Laboratories for undergraduate biology at the University of Kansas
Elena Solovyeva, post-doctoral fellow, 2001-2003, currently a specialist manager at Delrus-DiaMed,Moscow, Russia
Kevin V. King, post-doctoral fellow, 1999-2002, currently a senior scientist at Midwest Research Institute, Kansas City, KS
Bernd Eichenmueller, post-doctoral fellow, 1997-2000, Vice-President of Operations, Boehringer Ingelheim-Vetmedica, St. Josephs, MO
Suresh Tiwari, post-doctoral fellow, 1989-1991, currently Dean of Faculty and Prof. in the Biology Department, DQ University, Davis, CA
Denise Lepley, post-doctoral fellow, 1997-1998, currently a senior post- doctoral fellow at University of Connecticut, Farmington
SERVICE DEPARTMENTAL
Howard Hughes Scholarship Selection Committee, 1988-1991
Chair and member, Graduate Fellowship Committee, 1988-1990, 1992
Director of Graduate Studies, 1988-1990, 1997-1998
Graduate Education Committee, 1988-1990
Faculty Search Committee, 1988-1989, 1989-1990, 1990-1991, 1991-1992, 1993-1994, 1997-1998, 2000-2001, 2001-2002
Career Day host for Lawrence Junior High Schools, 1988
Laboratory workshop for Lawrence Junior High Gifted Children class, 1989
Graduate Admissions Committee, 1989-1998
Chair, Molecular Biology Seminar Series, 1990-1991
Faculty Senate Research Committee, 1990-1993
Committee on Graduate Studies (CGS), 1990-1993
Chair, GRF Committee, 1991, 1993-1994
Minority Fellowship Selection Committee, 1991-1992
Chair, Faculty Senate Research Committee, 1992-1993
Chair, CGS, 1992-1993
Promotion and Tenure Committee, 1992-1993; 2003-2004
Long Range Planning Committee, 1993-1994
Faculty Advisor, Women’s Rugby Team, 1993-1994
Faculty Search Committee, School of Pharmacy, 1993-1994
Laboratory workshop for state wide conference ‘Expanding Your Horizons in Science and Mathematics’, 1994, 1995
Referee for scientific papers at the Kansas-Nebraska-Oklahoma Regional Junior Science and Humanities Workshop, 1994
Health Alliance Committee (Premedical Advisory Committee), 1994-1995
Faculty Advisor, BioEthics Club, 1994-1995
Assessment of General Education, 1995, 2007
Curriculum Committee, 1998-2000
Honors and Awards Committee, 1999-2004
Research Collaboration and Funding Committee, 2003-2004
Graduate Recruiting Committee, 2003-2004
Section Head, Molecular, Cellular and Developmental Biology Group, 2004
Department Chair, Molecular Biosciences, 2004-2008
Division Co-Chair, Biological Sciences, 2006-2008
Chair, Outreach and Fundraising for Division of Biological Sciences, 2006-2008
Member, Promotion and Tenure Committee, 2010-2013
Member, Faculty Evaluation Committee, 2011-2014
Member of GRF review Committee, 2010-2011
Member, Department of Molecular Biosciences Executive Committee, 2013
Member, Steering Committee, Biological Sciences Alumni Board, 2013
Member, Full professor Promotion and Tenure Committee, 2014-2016
SERVICE COLLEGE AND UNIVERSITY
General Research Fund (GRF) Committee, 1988-1989, 1991, 1992-1994, 2011-2013
Chair, GRF Committee, 1991, 1993-1994
Career Day host for Lawrence Junior High Schools, 1988
Laboratory workshop for Lawrence Junior High Gifted Children class, 1989
Faculty Senate Research Committee, 1990-1993
Chair, Faculty Senate Research Committee, 1992-1993
Committee on Graduate Studies (CGS), 1990-1993
Chair, CGS, 1992-1993
Minority Fellowship Selection Committee, 1991-1992
Faculty Advisor, Women’s Rugby Team, 1993-1994
Faculty Search Committee, School of Pharmacy, 1993-1994
Laboratory workshop for state-wide conference ‘Expanding Your Horizons in Science and Mathematics’, 1994, 1995
Referee for scientific papers at the Kansas-Nebraska-Oklahoma Regional Junior Science and Humanities Workshop, 1994
Health Alliance Committee (Premedical Advisory Committee), 1994-1995
Faculty Advisor, BioEthics Club, 1994-1995
Assessment of General Education, 1995
Laboratory workshop for Parent’s Day, 1995-1996
Chancellor’s Teaching Awards Committee, 1997-1998
NSF Epscore Executive Committee for Developmental Genetics Grant, 1997-1999
Mentoring Program for Freshman and Sophomore Female Students, Emily Taylor Resource Center, 1998-2016
College Committee on Promotions and Tenure, 2001-2004
Mentor, Dean’s Scholars Program, 2002
Mentor, McNair Scholars Program, 2002
Steering Committee, Chemical Biology Training Grant, 2002-2005
SELF Graduate Fellowship Selection Committee, 2003-2004
University Scholars Selection Committee, 2003-2004
Search Committee for Senior Vice Provost for Research, 2003-2004
Five Year Review Committee for TORP Center, 2004
Undergraduate Research Awards Committee, 2004
Search committee, chair, Pharmaceutical Chemistry, 2004
SERVICE COLLEGE AND UNIVERSITY
KU-Lawrence Kansas Economic Growth Act Committee, 2004
Bicampus Life Sciences Committee, 2004-2008
Search Committee for Dean, College of Liberal Arts and Sciences, 2005-2006
Target Initiation and Review Group, 2008
Chancellor’s Athletic Advisory Committee, 2011-2014
Academic Integrity Subcommittee of Athletic Advisory Committee, 2011-2014
University Governance Athletic Advisory Committee, 2011-2014
College Academic Council, 2011-2014
Faculty Senate, 2012-2014
University Senate, 2012-2014
Faculty Senate Executive Board, 2013-2014
University Committee on Promotion and Tenure, 2014
Standing member, Academic Misconduct Committee, CLAS, 2015-2016
SERVICE NATIONAL AND INTERNATIONAL
Laboratory host to Ms. Sharon Begley, Senior Science Editor for Newsweek, Marine Biological Laboratory, Woods Hole, MA. 1987
Reviewer of manuscripts for Journal of Cell Biology, PNAS, Molecular and Cellular Biology, Journal of Cell Science, Cell Motility and the Cytoskeleton, Biochemistry, Journal of Biological Chemistry, Molecular Biology of the Cell, Journal of Biological Chemistry, ACS Nano, European Journal of Cell Biology, Central European Journal of Biology, 1987-2016
Member, Neuronal and Glial Mechanisms Grants Advisory Panel, NSF, 1991-1992
Member, Cellular Organization Grants Advisory Panel, NSF, 1997-2003
External Review Committee for the Department of Biological Sciences, University of South Carolina, Charleston, 2000.
Ad hoc reviewer for the Netherlands Organization for Scientific Research, The Hague, The Netherlands; Ministry for Education, Marousi, Greece ; biotechnology and Biological Ressearch Council, United Kingdom, 2001-2016
Laboratory host for Prof. Adolf Wainson, Director, Laboratory of Radiation Methods for Tumor Research, Russian Cancer Research Center, Moscow, 2002-2003
Editorial Board, Biological Bulletin, Woods Hole, MA, 2010-2013
Member, NSF Pre-proposal Review Panel for Division of Integrative Organismal System, 2013
PEER-REVIEWED PUBLICATIONS
Suprenant, K.A. and Dentler, W.L. (1982). Association between endocrine pancreatic secretory granules and in vitro-assembled microtubules is dependent upon microtubule-associated proteins. Journal of Cell Biology 93:164-174.
Rebhun, L.I., Suprenant, K.A., Keller, T.C.S., and Folley, L. (1982). Spindle and cytoplasmic tubulins from marine eggs. Cell Differentiation 11:367-371.
Suprenant, K.A. and Rebhun, L.I. (1983). Assembly of unfertilized sea urchin egg tubulin at physiological temperatures. Journal of Biological Chemistry 258:4518-4525.
Suprenant, K.A. and Rebhun, L.I. (1984). Purification and characterization of oocyte cytoplasmic tubulin and meiotic spindle tubulin of the surf clam, Spisula solidissima. Journal of Cell Biology 98:253-266.
Suprenant, K.A. and Rebhun, L.I. (1984). Cytoplasmic tubulin from unfertilized sea urchin eggs. II. Variation in the intrinsic calcium sensitivity of Strongylocentrotus purpuratus egg tubulin as a function of temperature and brain microtubule associated proteins. Cell Motility 4:333-350.
Suprenant, K.A., Hays, E., LeCluyse, E. and Dentler, W.L. (1985). Multiple forms of tubulin in the cilia and cytoplasm of Tetrahymena thermophila. Proc. Natl. Acad. Sci. USA. 82:6908-6912.
Suprenant, K.A. and Marsh, J.C. (1987). Temperature and pH govern the self-assembly of microtubules from unfertilized sea urchin egg extracts. Journal of Cell Science 87:71-84.
Suprenant, K.A. and Dentler, W.L. (1988). Release of intact microtubule capping structures from Tetrahymena cilia. Journal of Cell Biology 107:2259-2269.
Suprenant, K.A., Tempero, L.B., and Hammer, L.E. (1989). The association of ribosomes with in vitro assembled microtubules. Cell Motility and the Cytoskeleton 14:401-415.
Suprenant, K.A. (1991). Unidirectional microtubule assembly in cell-free extracts of Spisula solidissima oocytes is regulated by subtle changes in pH. Cell Motility and the Cytoskeleton 19:207-220 (AND COVER).
Suprenant, K. A. (1992). Particulate tubulin in interphase and metaphase extracts of Spisula oocytes. Biol. Bull. (Woods Hole) 183:200-210.
Suprenant, K.A., Dean, K., McKee, J. and Hake, S. (1993). EMAP-an echinoderm microtubule-associated protein found in microtubule-ribosome complexes. Journal of Cell Science. 104:445-456.
Wang, W., Suprenant, K. A., and Dentler, W. L. (1993). Reversible association of a 97 kD protein complex found at the tips of ciliary microtubules with in vitro assembled microtubules. Journal of Biological Chemistry 268:24797-24807.
Tiwari, S. and Suprenant, K.A. (1993): A pH and temperature-dependent cycling method that doubles the yield of microtubule protein. Analytical Biochemistry 215:96-103.
Tiwari, S. and Suprenant, K.A. (1994): On the pH-dependent solubility and assembly of tubulin in bovine brain extracts. Cell Motility and the Cytoskeleton. 28:69-78.
Hamill, D., Davis, J., Drawbridge, J. and Suprenant, K.A. (1994): Polyribosome targeting to microtubules: Enrichment of specific mRNAs in a reconstituted microtubule preparation from sea urchin embryos. Journal of Cell Biology 127: 973-984.
Li, Q. and Suprenant, K.A. (1994): Molecular characterization of the 77 kD echinoderm microtubule-associated protein (EMAP): Homology to the b-transducin family. Journal of Biological Chemistry 269:31777-31784.
Brisch, E., Daggett, M. A. F., and Suprenant, K. A. (1996): Cell cycle-dependent phosphorylation of the 77 kD echinoderm microtubule-associated protein (EMAP) and association with the p34cdc2 kinase. Journal of Cell Science 109, 2885-2893.
Hamill, D. and Suprenant, K. A. (1997): Characterization of the sea urchin major-vault protein: a possible role for vault ribonucleoprotein particles in nucleocytoplasmic transport. Developmental Biology 190:117-128.
Hamill, D. R., Howell, B., Cassimeris, L. and Suprenant, K. A. (1998): Purification of a WD-repeat protein, EMAP, and effects on microtubule dynamics. Journal of Biological Chemistry 273:9285-9291.
Daggett, M.A.F., Li, Q., Weaver, R. F. and Suprenant, K. A. (1998): Overexpression of the 77-kD echinoderm microtubule-associated protein (EMAP), a WD-repeat protein, in baculovirus-infected Sf9 cells. Cell Motility and the Cytoskeleton 41:57-67.
Li, Q., Callaghan, M. and Suprenant, K. A. (1998): The 77 kD echinoderm microtubule-associated protein (EMAP) shares epitopes with the mammalian brain MAPs, MAP-2 and tau. Biochem. Biophys. Res. Comm. 250:502-505.
Brisch, E., Ahrens, D. P., and Suprenant, K. A. (1999): Phosphatase-sensitive regulators of microtubule assembly copurify with sea urchin egg microtubules. Journal of Experimental Zoology 283:258-269.
Lepley, D.M., Palange, J.M., and Suprenant, K.A. (1999): The sequence and expression patterns of a human EMAP-related protein-2 (HuEMAP-2). Gene 237:343-349.
Suprenant, K. A., Tuxhorn, J.A., Daggett, M. A. F., Ahrens, D. P., Hostetler, A., Palange, J. M., Van Winkle, C. E., and Livingston, B. T. (2000): Conservation of the WD-repeat, microtubule-binding protein, EMAP, in sea urchins, humans, and the nematode, C. elegans. Development, Genes and Evolution 210:2-10.
Eichenmüller, B., Ahrens, D., and Suprenant, K. A., (2001): Purification and binding characteristics of sea urchin EMAP. Cell Motility and the Cytoskeleton 50:161-72.
Eichenmüller, B., Everley, P., Palange, J., Lepley, D., and Suprenant, K. A. (2002): The human EMAP-like protein-70 is a microtubule destabilizer that localizes to the mitotic apparatus. Journal of Biological Chemistry 277:1301-1309.
Bode, C. J., Gupta, M.L., Reiff, E.A., Suprenant, K. A., Georg, G.I., and Himes, R.H. (2002): Epothilone and paclitaxel: unexpected differences in promoting the assembly and stabilization of yeast microtubules. Biochemistry 41: 3870-3874.
Gupta, M.L., Bode, C.J., Thrower, D.A., Suprenant, K.A., Bloom, K.S. and Himes, R.H. (2002): b-tubulin C354 mutations that severely decrease microtubule dynamics do not prevent nuclear migration in yeast Molecular Biology of the Cell 13(8): 2919-32.
Bode, C., Gupta, M.L., Suprenant, K.A. and Himes, R.H. (2003): The two a–tubulin isotypes in budding yeast have opposing effects on microtubule dynamics in vitro. EMBO Reports 4:94-99.
Eichenmüller, B., Kedersha, N., Solovyeva, E. Everley, P., Lang, J., Himes, R.H., and Suprenant, K.A. (2003): Vaults bind directly to microtubules via their caps and not their barrels. Cell Motility and the Cytoskeleton 56:225-236 (AND COVER).
Stewart, P.L., Makabi, M., Lang, J., Dickey-Sims, C., Robertson, A.J., Coffman, J.A. and Suprenant, K.A. (2005): Sea urchin vault structure, composition, and differential localization during development. BMC Developmental Biology 5:3 (e-pub 14 Feb 2005).
Rodriguez, A.J., Seipel, S.A., Hamill, D.R., Romancino, D.R., Di Carlo, M., Suprenant, K.A. and Bonder, E.M. (2005): Seawi–a sea urchin piwi/argonaute family member is a component of MT-RNP complexes RNA 11:646-656.
Foland, T.B., Dentler, W.L., Suprenant, K.A., Gupta Jr., M., and Himes, R.H. (2005) Paclitaxel-induced microtubule stabilization causes mitotic block and apoptotic-like cell death in a paclitaxel-sensitive strain of Saccharomyces cerevisiae Yeast 22:971-978.
Dickensen, N., Moore, D., Suprenant, K., and Dunn, R.C. (2007) Vault Ribonucleoprotein Particles and the Nuclear Pore Complex.
Photochem Photobiol. 83(3):686-91.
Suprenant, K.A., Bloom, N., Fang, J. and Lushington, G. (2007) The major vault protein is related to the toxic anion resistance protein (TelA) family. Journal of Experimental Biology.210:946-955.*✝
Hueston, J.L., Herren, G.P., Cueva, J.G., Buechner, M.J., Lundquist, E.A., Goodman, M.B., and Suprenant, K.A. (2008) The C. elegans EMAP-like protein, ELP-1 is required for normal touch sensation and associates with microtubules and adhesion complexes. BMC Developmental Biology 8:110 (E-pub 17 November, 2008)*.
*Noted as a highly accessed paper.
Hueston JL and Suprenant KA. (2009) Loss of dystrophin and the microtubule-binding protein ELP-1 causes progressive paralysis and death of adult C. elegans. Dev Dyn. 2009 Aug;238(8):1878-86.
PICTURE SHOW
Cell Press Curated Picture Show on Cell Curiosities. http://www.cell.com/cell_picture_show-cell-curiosities?utm_source=ECE001&utm_campaign=&utm_content=&utm_medium=email&bid=YKGS75F:W050I1F
REVIEWS AND BOOK CHAPTERS
Suprenant, K.A. (1986). Tubulin-containing structures. Methods in Cell Biology 27:189-215.
Suprenant, K.A., Hays, E., LeCluyse, E. and Dentler, W.L. (1986). Tubulin heterogeneity in the ciliate Tetrahymena thermophila. Ann. N. Y. Acad. Sci. 466:132-133.
Dentler, W.L. and Suprenant, K.A. (1986). Isolation of microtubule-secretory granule complexes from the anglerfish endocrine pancreas. Ann. N. Y. Acad. Sci. 466:813-831.
Suprenant, K.A. (1993). Microtubules, ribosomes, and mRNA: Evidence for cytoplasmic localization and translational regulation. Cell Motility and the Cytoskeleton 25:1-10.
Suprenant, K.A. and Daggett, M. A. (1995): Sea Urchin Microtubules. Current Topics in Developmental Biology 31:65-99.
Suprenant, K.A. (2002): Vault ribonucleoprotein particles; sarcophagi, gondolas or safety deposit boxes? Biochemistry 41: 14447-14454.
REFERENCES: Available upon request
KATHY SUPRENANT 